Home · Rejuran vs Nucleofill Compared
A closer comparison than most. Both are polynucleotide boosters, no published trial puts one ahead of the other, and the choice should follow the diagnosis rather than the brand.
Both are polynucleotide skin boosters, so this is a closer comparison than Profhilo versus Rejuran. In practice Rejuran is directed more at repair, texture and pore refinement, and Nucleofill more at firmness and dermal quality — it is often chosen for the neck, jawline and under-eye area. There are no published head-to-head trials between the two brands, so anyone telling you one is definitively superior is expressing a preference, not citing evidence.
Repair-led
Firmness-led
Both products are frequently marketed as “PDRN”, and the terms get used interchangeably in clinic brochures. They are not identical. PDRN — polydeoxyribonucleotide — refers to shorter fragments than the longer-chain polynucleotides. It matters less to your result than the marketing suggests, but it matters when you are comparing two products and trying to work out whether you are comparing like with like. You usually are not.
Comparative trials between aesthetic injectable brands are rare, expensive and commercially unattractive to the manufacturers who would have to fund them. What exists instead is each brand's own evidence, clinician familiarity, and preference built from experience. That is a legitimate basis for a recommendation. It is not the same thing as proof, and we would rather say so than dress a preference up as science.
What this means practically: choose the clinic and the doctor, then let the product follow from the diagnosis. Product loyalty in a patient is usually a sign that someone has been marketed to.
Both are polynucleotide-based, neither adds volume, and both need a course rather than a single session followed by maintenance. Both are supplied through authorised distributors and arrive in sealed packaging with batch numbers — you are entitled to see the box opened in front of you, for either product, at any clinic. Both act on skin quality rather than on structural descent, so neither is the answer to a sagging jawline.
Rejuran is salmon-derived, so a fish allergy must be declared at consultation.
Pick the diagnosis, not the brand.
Send a photograph and your concern. dr. Jesslyn will tell you what is appropriate — or whether a different treatment is.
Book a dermatologist consultation Replies Monday–Saturday 9.30am–7pm WITA, usually within 30 minutes.What is the difference between Rejuran and Nucleofill?
Both are polynucleotide skin boosters. Rejuran, from PharmaResearch in South Korea, is directed more at repair, texture and pore refinement. Nucleofill, from Promoitalia in Italy, is a polymerised polynucleotide-based gel directed more at dermal firmness, and is often chosen for the neck, jawline and under-eye area.
Which is better, Rejuran or Nucleofill?
There are no published head-to-head trials between the two brands, so the honest answer is that neither is demonstrably better. The choice is a clinical judgement based on what your skin needs, not an evidence-based ranking.
Are Rejuran and Nucleofill both PDRN?
Both are commonly marketed as PDRN, but the terms are not interchangeable. PDRN — polydeoxyribonucleotide — refers to shorter fragments than longer-chain polynucleotides. The distinction matters when you are trying to compare two products like for like.
How many sessions does each need?
Rejuran is typically three to four sessions spaced two to four weeks apart. Nucleofill is typically two sessions a month apart, followed by maintenance. Both are courses rather than single treatments.
Do either of them add volume?
No. Neither is a dermal filler. Both act on skin quality and firmness rather than adding volume, and neither addresses structural descent such as a sagging jawline.
How do I know the product is genuine?
Both are supplied through authorised distributors and arrive in sealed manufacturer packaging with batch numbers. You are entitled to see the box opened in front of you before treatment, at any clinic, for either product.
Is there an allergy risk?
Rejuran polynucleotides are purified from salmon DNA, so a fish allergy must be declared at consultation. Any known hypersensitivity should be raised before treatment regardless of which product is being considered.
Medically reviewed by dr. Jesslyn Amelia, Sp.D.V.E — Dokter Spesialis Dermatologi, Venereologi dan Estetika. Registered with the Indonesian Ministry of Health, STR JT00000382760637. Verify registration. Last reviewed 8 September 2026. Individual results vary; this page is general information and not a substitute for consultation.